Investigators have discovered that some type of protective system goes into action in some cases when a baby’s immune system is deficient. This discovery indicates a hidden safety net that might have far-reaching consequences for treating diseases of the immune system such as AIDS. The Mayo Clinic-led study was conducted with colleagues in Toronto and Baltimore, and is reported in the early online edition of the Feb. 1 Journal of Immunology.
The researchers studied 20 patients who as infants underwent heart transplantation and had their thymus removed. As a result the infants were deficient in T cells, the cells depleted in AIDS patients that are crucial to fighting viruses and cancer tumors. The researchers found that over a 10-year-period the infant transplant patients resisted the same infections that often kill adult AIDS patients. The transplant patients maintained their health even with low T cell counts. The finding could help improve treatments of AIDS, cancers and diseases of aging related to declining function of the immune system.
“We are very excited by this result,” says Jeffrey Platt, M.D., the Mayo transplant researcher who led the team. “This will be the first step to discovering how to make the immune system work in patients who have severe defects in their immune systems or who have cancer.”
The Mayo Clinic researchers report results comparing T cell function between transplant patients 1-10 years post transplant and healthy people matched to the transplant patients by age and gender. To compare T cell function, they measured the T cell response to select viral immunization. This comparison enabled them to see that infant heart transplant patients had more help from the immune system post transplant — even though some had a 10,000-fold reduction in T cells — compared to the healthy control group. The nature of the compensating system is not yet known and is under study.
The findings are important because they show the immune system is more adaptable and resourceful than once thought. Something other than T cells is working to resist viruses in the post-transplant patients.
The findings also suggest an intriguing strategy for developing new treatments for AIDS, cancers and diseases of impaired immune function related to aging. If this ability of infant-transplant patients’ immune systems can be identified and enlisted to fight viruses without T cells, it perhaps could be therapeutically manipulated in adult patients to arrive at new and better treatments for various diseases involving immune system deficiencies.
“We were struck by the fact that when a heart transplant is carried out in very young infants, the thymus that produces T cells is removed and a drug is given that depletes T cells,” said Dr. Platt. “Yet the infants don’t get the same diseases that adult AIDS patients do, even though the transplanted infants are basically a model of AIDS. In fact, the post-transplant patients do very well resisting infections. It seemed to us very important to understand why this is so, because maybe that would help us help people with age-related diseases caused by declining immunity, or AIDS, or cancers, and understand why certain people tend to be more susceptible to infections.”